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Welcome to the beta environment of Supverse

Supverse is a media platform run by analysts and journalists.
Supverse, the UniVerse of WasSup, allows members to create ad hoc discussions on any page* across the vast Internet. The discussion can be just a reference for yourself, or a diverse audience debate. Organize all research content and references using personal hashtags on your Supverse profile and even stitch together these thoughts into a dynamic presentation you can publish online and share with others. Mingle your philosophies with others in the Supverse global sensorium to create new meanings.
  • Receive personalized emails with new comments made on pages you subscribed to, without signing up.
  • Sign up for a free account and use the cloud to bookmark pages and to leave notes on websites that interest you.
  • Join the discussions that are ongoing, see what trends and becomes news to you, find associated information.
  • Create an online dynamic stream of thought, in a Prezi like environment, and share it with like-minded people.


* At this point not every site is supported.

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Supverse
Filtered on: ncbi.nlm.nih.gov > showing 4 comments covering 100 days


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Tendon and Ligament Regeneration and Repair: Clinical Relevance and Developmental Paradigm


Decades of research on tendon and ligament (T/L) injuries have yielded extensive knowledge of the mechanical and biological properties of these dense connective tissues, translating into advances in surgical and conservative therapies that can prevent major disability. However, T/L injuries remain a persistent clinical challenge. In the U.S. alone, tendon, ligament, and joint capsular injuries account for 45% of the 32 million musculoskeletal injuries each year (Butler et al., 2004), with rates rising due to increasing sports participation and an aging population. Unfortunately, current treatment strategies fail to restore the functional, structural, and biochemical properties of repaired T/L to those of native tissue. Consequently, the principal elements of tissue engineering cells, scaffolds, and bioactive molecules have been explored in an effort to improve T/L healing. Both in vitro and in vivo studies have expanded the understanding of T/L biology while demonstrating the utility of tissue engineering in enhancing the healing of musculoskeletal tissues. Nevertheless, no tissue engineered construct thus far has achieved complete regeneration of T/L. In response, tissue engineers are looking to the emerging understanding of T/L development in an effort to recapitulate the embryonic events that establish the native structure (Thomopoulos et al., 2010). While researchers are only beginning to explore methods of integrating developmental biology into the design process, such efforts may advance the field of T/L tissue engineering towards its ultimate goal, full restoration of normal mechanical and biological properties (Lenas et al., 2009a). In this review, we will begin with the present understanding of tendon development. Ligament development has not received as much attention as that of tendon, but lessons learned from the latter should be applicable to the former, as tendons and ligaments possess similar ultrastructure and physiology, as well as fulfilling similar functional roles (Tozer and Duprez, 2005). The natural healing cascade of T/L will be summarized, as current therapeutic approaches to the three most common tendon injuries tears of the rotator cuff, Achilles tendon, and flexor tendon of the hand will be reviewed. Next, an overview of the current tissue engineering strategies to improve tendon healing, including cells, growth factors, scaffolds, and mechanical stimulation, will be provided. In closing, we will briefly explore the current limitations to tendon and ligament regeneration before offering future directions to address these challenges.
&neo 2017-11-14  


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The #RoleOfSuppression in figurative #language #comprehension


In this paper, we describe the crucial role that suppression plays in many aspects of language comprehension. We define #suppression as a general, #cognitive #mechanism , the purpose of which is to attenuate the interference caused by the activation of extraneous, unnecessary, or inappropriate information. #LawOfSuppression
&neo 2015-04-09  


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The relevance of theobromine for the beneficial effects of cocoa consumption


Apart from the high content of antioxidants, solid evidence points to methylxanthines as key players in the beneficial effects. #Caffeine has been classically considered with higher potential than other #methylxanthines . Recent studies have highlighted the potential of theobromine, which may act as antitumoral, anti-inflammatory or cardiovascular protector molecule without the undesirable side effects described for caffeine. The main mechanisms of action of #theobromine are inhibition of phosphodiesterases and blockade of adenosine receptors but, interestingly, it exhibits other important adenosine receptor-independent effects as the reduction of cellular oxidative stress or regulation of gene expression. In this sense, theobromine could be considered a safe and #NaturalAlternative in the treatment of some human #diseases and may serve as lead compound for the development of novel #drugs
&neo 2020-02-10  


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Levels of nicotine in Ethiopian tobacco leaves


#nicotine gum is around 2 mg to 4 mg .
&neo 2019-08-10  


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