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1 comment on ncbi.nlm.nih.gov/pmc/articles/PMC4335269

The relevance of theobromine for the beneficial effects of cocoa consumption

Apart from the high content of antioxidants, solid evidence points to methylxanthines as key players in the beneficial effects. #Caffeine has been classically considered with higher potential than other #methylxanthines. Recent studies have highlighted the potential of theobromine, which may act as antitumoral, anti-inflammatory or cardiovascular protector molecule without the undesirable side effects described for caffeine. The main mechanisms of action of #theobromine are inhibition of phosphodiesterases and blockade of adenosine receptors but, interestingly, it exhibits other important adenosine receptor-independent effects as the reduction of cellular oxidative stress or regulation of gene expression. In this sense, theobromine could be considered a safe and #NaturalAlternative in the treatment of some human #diseases and may serve as lead compound for the development of novel #drugs
&neo 2020-02-10 00:29:21