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| Ursolic Acid - an overview | ScienceDirect Topics #UrsolicAcid Ursolic acid is a lipophilic pentacyclic triterpenoid, especially abundant in apple peel, with anti-inflammatory and antihyperlipidemic properties [46]. Recently, ursolic acid has been identified as a possible remedy for muscle atrophy in a screen for small-molecule inhibitors of skeletal muscle wasting in mice [47]. Interestingly, supplementation with ursolic acid to mice on a high-fat diet increased muscle mass and strength, improved glucose tolerance, promoted brown adipose tissue deposition, and decreased white adipose tissue mass and the severity of hepatic steatosis [48]. These findings suggest that ursolic acid might represent an effective nutritional aid to counteract age-related changes in body composition and metabolic derangements. However, the effect of supplementation with ursolic acid in older adults with sarcopenia has yet to be investigated. &neo 2020-01-21 23:32:16 |